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KMID : 0616120100410020103
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Korean Journal of Pharmacognosy
2010 Volume.41 No. 2 p.103 ~ p.107
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Sesquiterpene Glycosides from the whole Plant Extract of Youngia japonica
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Kim Mi-Ri
Kim Young-Ho
Kim Young-Kyoon
Cha Mi-Ran
Choi Chun-Whan
Choi Sang-Un
Kim Young-Sup
Ryu Shi-Yong
Choi Yeon-Hee
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Abstract
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Extensive phytochemical investigation of the methanol extract from the whole plant of Youngia japonica (Asteraceae) led us to the isolation of a new guaiane-type sesquiterpene (1), together with three related guaianolides, youngiajaponicoside A (2), crepiside H (3) and crepeside E (4). The chemical structure of 1 was elucidated by the aid of spectroscopic analyses including 2D-NMR experiments (COSY, HMBC, HMQC and ROESY). The isolated components (1-4) were evaluated for the inhibitory effect on the proliferation of four cultured human tumor cell lines such as A549, SK-OV-3, SK-MEL-2 and HCT-15, in vitro.
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KEYWORD
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Youngia japonica, Asteraceae, sesquiterpene, tumor cell proliferation
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